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FRED (A Framework for Reconstructing Epidemiological Dynamics) is an open source modeling system developed by the Pitt Public Health Dynamics Laboratory in collaboration with the Pittsburgh Supercomputing Center and the School of Computer Science at Carnegie Mellon University.

FRED supports research on the dynamics of infectious disease epidemics and the interacting effects of:

The system uses agent-based modeling based on census-based synthetic populations that capture the demographic and geographic distributions of the population, as well as detailed household, school, and workplace social networks. Multiple circulating and evolving strains can be simulated. Mitigation strategies in the framework include vaccination, anti-viral drugs, and school closure policies. FRED supports models of health behavior change to facilitate the study of critical personal health behaviors such as vaccine acceptance, personal hygiene and spontaneous social distancing.

FRED is available through open source in the hopes of making large-scale agent-based epidemic models more useful to the policy-making community, the research community, and as a teaching tool for students in public health.


If you use FRED in your research, please use the following citation:

Grefenstette JJ, Brown ST, Rosenfeld R, Depasse J, Stone NT, Cooley PC, Wheaton WD, Fyshe A, Galloway DD, Sriram A, Guclu H, Abraham T, Burke DS. FRED (A Framework for Reconstructing Epidemic Dynamics): An open-source software system for modeling infectious diseases and control strategies using census-based populations. BMC Public Health, 2013 Oct;13(1), 940. doi: 10.1186/1471-2458-13-940. PubMed PMID: 24103508


Support for this work is provided by the National Institute of General Medical Sciences under MIDAS grant 1U54GM088491-01, by the Vaccine Modeling Initiative funded by the Bill and Melinda Gates Foundation, and by the Robert Wood Johnson Foundation.