FRED Phase II Simulator for Opioid Use Disorder and Overdose

The CDC has requested substantial additions and updates to the Opioid Use Disorder (OUD) Model creased under Phase I. The additions requested include:

  • Increased clinical detail regarding the clinical progression of OUD
  • Additional detail incorporating polysubstance use
  • Expanded detail regarding the downstream consequences of OUD (non overdose but OUD-related mortality)
  • An increase in the number and characterization of the model's representation of prevention and treatment, including expanded MOUD treatment (buprenorphine, methadone, naltrexone) as well as other mitigation strategies such as PMDPs, law enforcement interdiction, linkage of overdose to care, and several others
  • An expansion of the web-tool to allow for evaluation in all 3006 counties in the US


The FRED Phase II simulation is funded by: RFP 75D301-21-R-71948: Advancing Analytics to Improve Actionable Changes in the Opioid Overdose Epidemic – Phase II. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by CDC/HHS, or the U.S. Government.